1.  Good choice, Marvel.  Show the grand scope of the Marvel Universe through the eyes of the agents of S.H.I.E.L.D., supercops and superspies but ultimately normal men and women in an increasingly non-normal world.
2.  Colbie Smuthers reprising her role as Maria Hill on at least a recurring basis seems totally doable, doesn’t it?  “How I Met Your Mother” is surely winding down.
3.  We really need Neal McDonough as Agent Dum-Dum Dugan, Jr.  He will grow the mustache again, people.
4.  There was talk a couple years back about a Mockingbird TV series, reimagining her a college student / secret agent a la Alias.  In the comics, she recently got a less silly costume and a power-up from an experimental Infinity Formula / Super Soldier Serum combo.  I think there’s an origin in there — young biochemist gets Captain America-style enhancements and a crash course in escrima, becomes a field agent.  Romantic history with Hawkeye is optional, although I’d be fine with it if they just made her his ex-wife / ex-partner.
5.  The recent Kirkman Hickman S.H.I.E.L.D. series, which revealed S.H.I.E.L.D.’s roots as a secret Illuminati defending the world for thousands of years, is a rich source of storylines.
6.  Agent Coulson flashbacks aplenty, and any other way to get Clark Gregg in a black suit on this show, sure.  But no true resurrection, and I’m not sure we’re ready to skip straight to his LMD as a series regular.
7.  My pet idea for a point-of-view character — Rick Jones, played as a young drifter and inexplicable weirdness magnet.  Do a “Forrest Gump” digital insertion sequence where we see him wandering in the background of every earlier Marvel Universe movie, including his short-lived job at the shawarma place.
8.  Is it crazy to think that a couple of Very Special Episodes could feature, say, Tony Stark making an appearance at the Helicarrier?  Or an occasional Sam Jackson on a video screen?
9.  HYDRA survived WWII, and has gone underground as the all-purpose Evil Spy Organization.  Baron Wolfgang Von Strucker is 115 years old, kept alive by Nazi Super Science (i.e., the stuff that will let Bucky return in the Captain America sequel) and pure evil. 
10.  I’m thinking Jessica Drew as a spider-powered double agent might work, and it’s as close as we’re gonna get to adding Spider-Man to the Marvel Cinematic Universe.